Omeprazole & Metformin Warning: Are You At Risk of B12 Deficiency? (2026)

A pharmacist has issued a critical warning to individuals taking omeprazole or metformin, highlighting a list of symptoms that could indicate a vitamin B12 deficiency. These symptoms include numbness and a red tongue, which can be easily overlooked. Niamh McMillan, a Superdrug Pharmacy Superintendent, emphasizes the importance of recognizing these signs, especially for those on long-term acid-reducing treatments. Vitamin B12 is crucial for nerve and blood cell health, and a deficiency can develop gradually, making symptoms hard to detect initially. Common signs include persistent tiredness, shortness of breath, headaches, dizziness, pale skin, and a sore or red tongue. Other symptoms may include pins and needles, numbness in hands or feet, memory issues, concentration problems, or low mood. B12 deficiency occurs when the body lacks sufficient vitamin B12 or struggles to absorb it effectively. This condition is more prevalent in vegans and vegetarians, as B12 is primarily found in animal products. It can also affect older adults, those with digestive disorders like coeliac disease or Crohn's disease, and individuals taking specific medications, including long-term acid-reducing treatments such as proton pump inhibitors or metformin. To prevent B12 deficiency, incorporating dietary sources is essential. Foods rich in vitamin B12 include meat, fish, eggs, milk, cheese, and yogurt. Fortified foods like breakfast cereals and plant-based milks are also beneficial, especially for those avoiding animal products. In some cases, supplements may be necessary, particularly if dietary intake is limited or absorption is compromised. If individuals experience symptoms or are at higher risk of deficiency, consulting a healthcare professional is advised. A simple blood test can determine B12 levels, and early treatment can prevent long-term complications. Superdrug Health Clinics offer a Vitamin B12 Injection Service at selected UK locations, following a clinical assessment or evidence of deficiency. Several medications can interfere with B12 absorption or processing, including proton pump inhibitors (PPIs), H2 blockers, metformin, oral contraceptives, colchicine, anticonvulsants, nitrous oxide, and antibiotics. Individuals taking these medications long-term should monitor for symptoms such as fatigue, pins and needles, brain fog, or a sore, red tongue. A blood test can check B12 levels, and many doctors now recommend periodic screening for patients on long-term metformin or PPIs.

Omeprazole & Metformin Warning: Are You At Risk of B12 Deficiency? (2026)
Top Articles
Latest Posts
Recommended Articles
Article information

Author: Nicola Considine CPA

Last Updated:

Views: 5813

Rating: 4.9 / 5 (69 voted)

Reviews: 84% of readers found this page helpful

Author information

Name: Nicola Considine CPA

Birthday: 1993-02-26

Address: 3809 Clinton Inlet, East Aleisha, UT 46318-2392

Phone: +2681424145499

Job: Government Technician

Hobby: Calligraphy, Lego building, Worldbuilding, Shooting, Bird watching, Shopping, Cooking

Introduction: My name is Nicola Considine CPA, I am a determined, witty, powerful, brainy, open, smiling, proud person who loves writing and wants to share my knowledge and understanding with you.